Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy

Abstract Background Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer.The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highly invasive triple negative breast cancer (TNBC).Methods We examined the antitumor action of CSMD1 in three TNBC cell lines

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What factors influence smoking prevalence and smoke free policy enactment across the European Union Member States.

Smoking prevention should be a primary public health priority for all governments, and effective preventive policies have been identified for decades.The heterogeneity of smoking prevalence between European Union (EU) Member States therefore reflects, at least in part, a failure by governments to prioritise public health over tobacco industry or po

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Association between in situ ventilation and human-generated aerosol exposure in meatpacking plants during the COVID-19 pandemic.

During the COVID-19 pandemic, meatpacking workers were disproportionately affected by disease.Large outbreaks at meatpacking facilities resulted in loss of life and threatened the well-being of workers across the globe.Much work was done throughout the pandemic to understand and prevent these outbreaks.This study combined ventilation system evaluat

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